Interchangeability of medications and biopharmaceutical implication of taking drugs with fluids other than water: ibuprofen case study

The aim of this study was to compare the dissolution properties ibuprofen solid oral dosage forms commercially available in Bosnia and Herzegovina estimate influence medium composition on drug release. Eight products (A-H) were subjected vitro test using experimental conditions described USP42-NF37. Dissolution one selected product examined presence alcohol (22.2% v/v) fruit juice v/v). Products marked B-H complied with pharmacopeial criteria. profile B similar profiles D, E, F G similarity also found between A-D, C-G, D-G E-F. Drug release from most preparations fitted best Weibull kinetic model. In medium, higher amount dissolved. Contrary, dissolved significantly lower. Differences investigated suggest that their interchangeability should be additionally considered demonstrated vivo bioequivalence studies. Presence different substances can affect ibuprofen, emphasizing importance patient’s compliance.